Effect of Environmental Temperature on Transdermal Drug Penetration
نویسندگان
چکیده
منابع مشابه
Effect of environmental temperature on transdermal drug penetration.
The effect of environmental temperature on the penetration from matrix-type transdermal patch of non-steroidal anti-inflammatory drugs (NSAIDs) as model drugs was investigated using in vitro and in silico experiment. The patch was applied on the stratum corneum (SC) side of the skin. The dermal side of the skin was mounted on a diffusion cell. The donor compartment of the diffusion cell was fil...
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Transdermal Delivery of Verapamil HCl: Effect of Penetration Agent on In Vitro Penetration through Rat Skin
Article history: Received on: 15/12/2012 Revised on: 24/02/2013 Accepted on: 11/03/2013 Available online: 30/03/2013 Verapamil Hydrochloride is a calcium channel blocking anti-anginal agent. Extensive first pass metabolism, low bioavailability (~20%) and short biological half life (4.8 hrs) altogether makes it an ideal candidate for transdermal drug delivery. The objectives of this study were t...
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The greatest hindrance for transdermal drug delivery (TDD) is the barrier property of skin, especially the stratum corneum (SC). Various methodologies have been investigated and developed to enhance the penetration of drugs through the skin. Among them, the most popular approach is the application of penetration enhancers (PEs), including natural terpenes, a very safe and effective class of PEs...
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Flynn, G.L., and B. Stewart: Percutaneous drug penetration: Choosing candidates for transdermal drug development. Drug Dev. Res. 13:169-185, 1988. There is currently a high level of interest in using the skin as a route for delivering drugs. One hears the questions: What are the attributes of a drug that make it a serious candidate for transdermal delivery? By what a priori analysis might one z...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2010
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.33.1983